Why is Alzheimer’s more common in women?

Two-thirds of Alzheimer’s patients are women. So far, on the grounds that women live on average longer than men. A study in the Online edition of "Neurology" the difference, however, hormonal changes during menopause.

85 women and 36 men aged between 40 and 65 years without signs of intellectual impairment took part in the study. In Thinking and memory tests men and women scored similarly, and also in relation to your blood pressure and a family history of Alzheimer’s disease do not differ.

In brain scans, it was then measured the amount of gray and white brain matter, and according to Amyloid-Beta Plaques that are for Alzheimer’s disease typical. In addition, the brain was tested activity by the glucose metabolism in the brain was measured. In all four areas, women performed worse than men: they had, on average, 30 percent more Beta-Amyloid Plaques in the brain, and glucose metabolism was 22 percent less than men. Women had substance in addition, on average, eleven percent less white and gray brain.

Hormones verächange after menopause

The study author Dr. Lisa Mosconi suspects: "Our results suggest that women have a higher risk for the disease, possibly due to lower levels of the hormone Estrogen during and after menopause. Probably all the sex hormones are involved, but in particular, the pattern of loss of gray matter shows an anatomical Overlap with the Estrogen-network of the brain."